SYNTHESIS OF 2,6-DIAMINO-5-HETARYLPYRIMIDINES AS POTENTIAL ANTIFOLATES
УДК 547.853.7
Keywords:
antifolate agents, diaminopyrimidines, 2-hetaryl-2-(tetrahydro-2-furanyliden)acetonitrilesAbstract
The ring transformation reactions of 2-hetaryl-2-(tetrahydro-2-furanyliden)acetonitriles with guanidine as 1,3-N,N-binucleophiles have been investigated. The method allows obtaining diaminopyrimidines, which have been of great interest in recent years due to their potent biological and pharmacological properties.
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Copyright (c) 2013 D. Milokhov, PhD-Student, O. Khilya, PhD, Yu. Volovenko, Professor
This work is licensed under a Creative Commons Attribution 4.0 International License.
